Prévalence de la transmission de virus résistant à la zidovudine en Suisse. L'étude suisse de cohorte VIH
| Autor: | Yerly Ferrillo, Sabine, Rakik, A., Kinloch-de-Loes, S., Erb, P., Vernazza, P., Hirschel, Bernard, Perrin, Luc |
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| Jazyk: | francouzština |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Drug Resistance/genetics Adolescent Base Sequence Molecular Sequence Data Middle Aged DNA Viral/genetics Polymerase Chain Reaction HIV Infections/ transmission Zidovudine/ pharmacology HIV/ drug effects/genetics Humans ddc:576.5 Female Antiviral Agents/ pharmacology HIV Reverse Transcriptase/genetics Retrospective Studies |
| Zdroj: | Schweizerische medizinische Wochenschrift, Vol. 126, No 43 (1996) pp. 1845-1848 |
| ISSN: | 0036-7672 |
| Popis: | Zidovudine (ZDV) was the most widely used anti-HIV drug between 1987 and 1995, and, as already reported, transmission of ZDV-resistant viruses occurs. Several mutations of the reverse transcriptase gene have been identified; one of them affects the 215 codon and is associated with a high degree of resistance. We have determined, using selective PCR, the prevalence of transmission of 215 mutant isolates in 134 patients with primary HIV infection (PHI) and have identified 8 patients with 215 mutant virus between 1989 and 1995 in Switzerland. Mutant resistant viruses have been isolated from patients treated with most antiviral drugs. A systematic search for mutant viruses may provide useful information for the adaptation of treatment strategies. |
| Databáze: | OpenAIRE |
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