Comparison of Intensive Chemotherapy and Hypomethylating Agents before Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndromes
| Autor: | Potter, Victoria T, Iacobelli, Simona, van Biezen, Anja, Maertens, Johann, Bourhis, Jean-Henri, Passweg, Jakob R, Yakhoub-Agha, Ibrahim, Tabrizi, Reza, Bay, Jacques-Olivier, Chevallier, Patrice, Chalandon, Yves, Huynh, Anne, Cahn, Jean Yves, Ljungman, Per, Craddock, Charles, Lenhoff, Stig, Russell, N H, Fegueux, Nathalie, Socié, Gerard, Bruno, Benedetto, Meijer, Ellen, Mufti, G J, de Witte, Theo, Robin, Marie-Claude, Kröger, Nicolaus |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
ddc:616
Adult Male Salvage Therapy Antimetabolites Remission Induction Middle Aged Survival Analysis Myelodysplastic Syndromes/drug therapy/mortality Antineoplastic Agents/standards/therapeutic use Young Adult Hematopoietic Stem Cell Transplantation/methods/mortality/standards Humans Female Aged Antineoplastic/standards/therapeutic use Follow-Up Studies Retrospective Studies |
| Zdroj: | Biology of Blood and Marrow Transplantation, Vol. 22, No 9 (2016) pp. 1615-1620 |
| ISSN: | 1083-8791 |
| Popis: | The European Society for Blood and Marrow Transplant Research data set was used to retrospectively analyze the outcomes of hypomethylating therapy (HMA) compared with those of conventional chemotherapy (CC) before hematopoietic stem cell transplantation (HSCT) in 209 patients with advanced myelodysplastic syndromes. Median follow-up was 22.1 months and the median age of the group was 57.6 years with 37% of the population older than > 60 years. The majority of patients (59%) received reduced-intensity conditioning and 34% and 27% had intermediate-2 and high international prognostic scoring system (IPSS) scores. At time of HSCT, 32% of patients did not achieve complete remission (CR) and 13% had primary refractory disease. On univariate analysis, outcomes at 3 years were not significantly different between HMA and CC for overall survival (OS), relapse-free survival (RFS), cumulative incidence of relapse (CIR), and nonrelapse mortality (NRM): OS (42% versus 35%), RFS (29% versus 31%), CIR (45% versus 40%), and NRM (26% versus 28%). Comparing characteristics of the groups, there were more patients < 55 years old, more patients in CR (68% versus 32%), and fewer patients with primary refractory disease in the CC group than in the HMA group (10% versus 19%, P |
| Databáze: | OpenAIRE |
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