| Autor: |
Ettouati, L., Casimir, J. R., Raynaud, I., Trescol-Biemont, M. C., Carrupt, Pierre-Alain, Gerlier, D., Rabourdin-Combe, C., Testa, Bernard, Paris, J. |
| Jazyk: |
angličtina |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Protein and Peptide Letters, Vol. 5, No 4 (1998) pp. 221-229 |
| ISSN: |
0929-8665 |
| Popis: |
The synthesis of the 53-54 ketomethylene isostere of HEL(52-61), an antigenic decapeptide, was realised by convergent Fmoc solid-phase peptide synthesis. In addition to the target peptide, an unexpected hydroxysuccinyl by-product was recovered. The two ketomethylene epimers did not exhibit any stimulating or competitive activity. Molecular modelling studies of the analogues-MHC-II I-A(k) complex suggested a departure from the canonical polyproline II conformation which could account for the absence of binding to I-A(k) molecule |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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