Asthma severity is associated with body mass index and early menarche in women.: Body mass index and asthma severity
| Autor: | Varraso, Raphaëlle, Siroux, Valérie, Maccario, Jean, Pin, Isabelle, Kauffmann, Francine |
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| Přispěvatelé: | Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), EGEA, Faraldo, Beatrice |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
MESH: Age Factors
MESH: Smoking MESH: Humans MESH: Asthma MESH: Time Factors MESH: Bronchial Hyperreactivity MESH: Adult macromolecular substances MESH: Forced Expiratory Volume MESH: Case-Control Studies MESH: Male respiratory tract diseases MESH: Body Mass Index MESH: Sex Factors MESH: Menarche immune system diseases MESH: Dyspnea [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Severity of Illness Index [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Female |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2005, 171 (4), pp.334-9. ⟨10.1164/rccm.200405-674OC⟩ |
| ISSN: | 1073-449X 1535-4970 |
| DOI: | 10.1164/rccm.200405-674OC⟩ |
| Popis: | International audience; Asthma severity in relation to body mass index (BMI) has rarely been studied. The relation between BMI and asthma severity was studied by sex in 366 adults with asthma from the Epidemiological Study on the Genetics and Environment of Asthma, a case-control and family study on asthma. Factors related to asthma severity and BMI such as smoking, FEV(1), bronchial hyperresponsiveness, and dyspnea were taken into account. The influence of early menarche was studied to assess the potential role of hormonal factors. Clinical asthma severity in the last 12 months was assessed by a score (0-7) based on the frequency of asthma attacks, persisting symptoms between attacks, and hospitalization. Asthma severity, which was unrelated to sex, increased with BMI in women (p = 0.0001) but not in men (p = 0.3). In women, the association remained after adjustment for age, FEV(1), smoking habits, and BMI-adjusted dyspnea and taking into account familial dependence (p = 0.0001). The association between BMI and severity was stronger in women with early menarche than in women without early menarche (p interaction = 0.02). Findings support the hypothesis of hormonal factors involved in the severity of asthma. |
| Databáze: | OpenAIRE |
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