Environnement, asthme sévère, allergie : EGEA
| Autor: | Siroux, Valérie, Oryszczyn, Marie-Pierre, Varraso, Raphaëlle, Le Moual, Nicole, Bousquet, Jean, Charpin, Denis, Gormand, Frédéric, Kennedy, Susan, Maccario, Jean, Pison, Christophe, Rage, Estelle, Scheinmann, Pierre, Vervloet, Daniel, Pin, Isabelle, Kauffmann, Francine |
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| Přispěvatelé: | Faraldo, Beatrice, Groupe de Recherche Sur Le Cancer du Poumon : Bases Moléculaires de la Progression Tumorale, Dépistage et Thérapie Génique, Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale (INSERM), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pneumologie-allergologie, Assistance Publique - Hôpitaux de Marseille (APHM), Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), School of Occupational & Environmental Hygiene, University of British Columbia (UBC), Département de médecine aiguë spécialisée, CHU Grenoble-Hôpital Michallon, Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Pneumologie-Allergologie [Hôpital de la Timone - APHM], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Convention INSERM-MSD, réseau INSERM de recherche clinique (489012) et de santé publique (493009), Ministère de la santé, Ministère de l'environnement, Direction de la Recherche Clinique du CHU de Grenoble et COMARES, EGEA |
| Jazyk: | francouzština |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Premenstrual Syndrome
MESH: Smoking MESH: Asthma MESH: Menopause MESH: Hypersensitivity asthme sévère allergie MESH: Phenotype MESH: Body Mass Index MESH: Eosinophils MESH: Risk Factors MESH: Child MESH: Environment MESH: Age Factors MESH: Epidemiologic Studies MESH: Humans MESH: Immunoglobulin E MESH: Biological Markers MESH: Bronchial Hyperreactivity MESH: Adult MESH: Case-Control Studies MESH: Male respiratory tract diseases Environnement asthme MESH: France MESH: Menarche [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Hypersensitivity Immediate MESH: Contraceptives Oral MESH: Female |
| Zdroj: | Revue des Maladies Respiratoires Revue des Maladies Respiratoires, Elsevier Masson, 2007, 24 (5), pp.599-608 |
| ISSN: | 0761-8425 1776-2588 |
| Popis: | International audience; INTRODUCTION: EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article. METHODS AND RESULTS: The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy (eosinophils, IgE and atopy) and hormonal dependent events in women (premenstrual asthma, menopause and oral contraceptive use) have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis. CONCLUSIONS: New hypothesis will be tested in the near future from the second stage of this survey. |
| Databáze: | OpenAIRE |
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