Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion
| Autor: | Shirley, Sarah, Morizot, Alexandre, Micheau, Olivier |
|---|---|
| Přispěvatelé: | Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, This work is supported by grants of the Conseil Regional de Bourgogne, the INCa (Institut National du Cancer), Cancéropôle Grand-Est, ANR (Agence Nationale de la Recherche, ANR-06-JCJC-0103 and 07-PCV-0031), and the European Community (ApopTrain Marie Curie RTN) (O.M.). A.M., is supported by fellowships from the Ministry of Research and Education and the ARC (Association pour la Recherche sur le Cancer). S.S. is supported by the INCa., ANR-06-JCJC-0103,TRAILCHIM,TRAIL et chimiothérapies anticancéreuses(2006), Micheau, Olivier, Programme 'Jeunes chercheuses et jeunes chercheurs' - TRAIL et chimiothérapies anticancéreuses - - TRAILCHIM2006 - ANR-06-JCJC-0103 - JCJC - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
MESH: Cell Death
MESH: Signal Transduction MESH: Humans MESH: Apoptosis Regulatory Proteins MESH: Apoptosis MESH: Models Biological [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Receptors TNF-Related Apoptosis-Inducing Ligand MESH: Cell Membrane |
| Zdroj: | Recent Pat Anticancer Drug Discov Recent Pat Anticancer Drug Discov, 2011, 6 (3), pp.311-23 |
| Popis: | Article Open access plus; International audience; The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement. |
| Databáze: | OpenAIRE |
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