Retinal microvascular alterations related to diabetes assessed by optical coherence tomography angiography: A cross-sectional analysis
| Autor: | Gozlan, Julien, Ingrand, Pierre, Lichtwitz, Olivier, Cazet-Supervielle, Agathe, Benoudis, Léa, Boissonnot, Michele, Hadjadj, Samy, Leveziel, Nicolas |
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| Přispěvatelé: | Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Pinet, Nicolas |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
capillary occlusion
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology genetic structures [SDV]Life Sciences [q-bio] OCT angiography ischemia retinal Imaging eye diseases [SDV] Life Sciences [q-bio] diabetic retinopathy macula sense organs capillary plexus [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Medicine Medicine, Lippincott, Williams & Wilkins, 2017, 96 (15), ⟨10.1097/MD.0000000000006427⟩ |
| ISSN: | 0025-7974 1536-5964 |
| DOI: | 10.1097/MD.0000000000006427⟩ |
| Popis: | International audience; Fluorescein angiography has been so far the gold-standard test to assess diabetic macular ischemia (DMI), a cause of irreversible visual impairment in diabetic patients. The aim of this study was to investigate foveal avascular zone (FAZ) and perifoveal microcirculation changes in eyes with nonproliferative diabetic retinopathy (NPDR) using optical coherence tomography angiography (OCTA), a new and noninvasive vascular imaging technique.Cross-sectional study including eyes of diabetic patients with NPDR.All patients underwent medical history, best-corrected visual acuity (BCVA) measurement, slit-lamp and fundus examination, multicolor imaging, SD-OCT, and swept-source OCT. OCTA was performed in order to assess macular superficial and deep capillary plexus, and swept-source OCT was performed to evaluate the central choroidal thickness.Fifty-eight eyes of 35 patients with a mean age of 61.8 years (±12.1) with mean HbA1C level of 7.6% (±1.5) were included in this study. Among them, 19 eyes had mild NPDR, 24 eyes had moderate NPDR, and 15 eyes had severe NPDR. There was a significant progression between NPDR stages for FAZ grade (P |
| Databáze: | OpenAIRE |
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