Rat Hepatitis E Virus
| Autor: | Parraud, Delphine, Lhomme, Sébastien, Péron, Jean Marie, da Silva, Isabelle, Tavitian, Suzanne, Kamar, Nassim, Izopet, Jacques, Abravanel, Florence |
|---|---|
| Přispěvatelé: | Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Néphrologie et Transplantation d'organes [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Benson-Rumiz, Alicia |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
immunocompromised
South-Western France [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases rodent [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases hepatitis E chronic hepatitis zoonosis rat hepatitis E virus epatitis E virus [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, 2021, 8, pp.726363. ⟨10.3389/fmed.2021.726363⟩ |
| ISSN: | 2296-858X |
| Popis: | International audience; Background: Hepatitis E Virus (HEV) is one of the most common causes of hepatitis worldwide, and South-Western France is a high HEV seroprevalence area. While most cases of HEV infection are associated with the species Orthohepevirus-A, several studies have reported a few cases of HEV infections due to Orthohepevirus-C (HEV-C) that usually infects rats. Most of these human cases have occurred in immunocompromised patients. We have screened for the presence of HEV-C in our region. Methods and Results: We tested 224 sera, mostly from immunocompromised patients, for HEV-C RNA using an in-house real time RT-PCR. Liver function tests gave elevated results in 63% of patients: mean ALT was 159 IU/L (normal < 40 IU/L). Anti-HEV IgG (49%) and anti-HEV IgM (9.4%) were frequently present but none of the samples tested positive for HEV-C RNA. Conclusion: HEV-C does not circulate in the human population of South-Western France, despite the high seroprevalence of anti-HEV IgG. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|