Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: The Tromsø study

Autor: Olsøy, Irene Beate, Henriksen, Stian, Weissbach, Fabian, Larsen, Marthe, Borgen, Karoline, Abravanel, Florence, Kamar, Nassim, Paulssen, Eyvind, Hirsch, Hans, Rinaldo, Christine Hanssen
Přispěvatelé: University Hospital of North Norway [Tromsø] (UNN), The Arctic University of Norway [Tromsø, Norway] (UiT), University of Basel (Unibas), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CARBILLET, Véronique
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Medical Microbiology and Immunology
Medical Microbiology and Immunology, 2019, 208 (6), pp.715-725. ⟨10.1007/s00430-019-00599-5⟩
ISSN: 0300-8584
1432-1831
DOI: 10.1007/s00430-019-00599-5⟩
Popis: International audience; Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40-79 years, were randomly selected from the 21,083 participants in the 7th Tromsø Study, representing the 32,591 inhabitants of the Tromsø municipality that were ≥ 40 years. All samples were analyzed by ELISA-1 (recomWell HEV IgG). Samples testing positive or borderline, as well as a 1.5-fold excess of negative samples, were retested by ELISA-2 (DiaPro HEV IgG). If still borderline or a result discordant from ELISA-1, the sample was retested by ELISA-3 (Wantai HEV IgG) and strip-immunoassay (recomLine HEV IgG). Anti-HEV IgG was detected in 205 individuals (11.4%), yielding an estimated seroprevalence of 10.4% in the age-matched population of Tromsø. Using logistic regression analysis followed by multivariable backward elimination analysis, increasing age (OR 1.036 per year; p < 0.001) and higher education (OR 2.167; p < 0.001) were found as potential risk factors, whereas travel abroad or eating of red meat were not. Our results indicate that HEV-infection is common in Northern Norway and suggest that HEV testing should be included in the evaluation of elevated liver enzymes.
Databáze: OpenAIRE
Externí odkaz: