Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.: Ethanol and AMPA receptors in the dorsomedial striatum
| Autor: | Wang, Jun, Ben Hamida, Sami, Darcq, Emmanuel, Zhu, Wenheng, Gibb, Stuart, Lanfranco, Maria Fe, Carnicella, Sebastien, Ron, Dorit |
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| Přispěvatelé: | Savasta, Marc, Cell Biology of Addiction in Neurology, Ernest Gallo Clinic and Research Center, Department of Neurology, University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), ANTE-INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement, Ernest Gallo Clinic and Research Center-Ernest Gallo Clinic and Research Center-Department of Neurology, University of California (UC)-University of California (UC)-University of California [San Francisco] (UC San Francisco), This research was supported by funds provided by the State of California for medical research on alcohol and substance abuse through the University of California, San Francisco (D.R.), by NIAAA (R01AA/MH13438) (D.R.) and (P50AA017072) (D.R. and J.W.), and by ABMRF/The Foundation for Alcohol Research (J.W.). |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Sulpiride
MESH: Ethanol MESH: Rats [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] MESH: Picrotoxin MESH: Neurons MESH: Conditioning Operant MESH: Rats Sprague-Dawley MESH: GABA Antagonists MESH: Choice Behavior MESH: Animals Newborn MESH: Corpus Striatum MESH: Long-Term Potentiation MESH: Quinoxalines MESH: Rats Long-Evans MESH: Analysis of Variance MESH: Patch-Clamp Techniques MESH: Up-Regulation [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] MESH: Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Excitatory Postsynaptic Potentials MESH: Food Preferences MESH: Sweetening Agents MESH: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid musculoskeletal neural and ocular physiology fungi MESH: Sucrose MESH: Electric Stimulation MESH: Excitatory Amino Acid Antagonists MESH: Male MESH: N-Methylaspartate MESH: Evoked Potentials nervous system MESH: Receptors AMPA MESH: Synaptosomes [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Central Nervous System Depressants MESH: Excitatory Amino Acid Agonists MESH: Self Administration MESH: Dopamine Antagonists |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, 2012, 32 (43), pp.15124-32. ⟨10.1523/JNEUROSCI.2783-12.2012⟩ |
| ISSN: | 0270-6474 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.2783-12.2012⟩ |
| Popis: | International audience; We found previously that acute ex vivo as well as repeated cycles of in vivo ethanol exposure and withdrawal, including excessive voluntary consumption of ethanol, produces a long-lasting increase in the activity of NR2B-containing NMDA receptors (NR2B-NMDARs) in the dorsomedial striatum (DMS) of rats (Wang et al., 2010a). Activation of NMDARs is required for the induction of long-term potentiation (LTP) of AMPA receptor (AMPAR)-mediated synaptic response. We therefore examined whether the ethanol-mediated upregulation of NMDAR activity alters the induction of LTP in the DMS. We found that ex vivo acute exposure of striatal slices to, and withdrawal from, ethanol facilitates the induction of LTP in DMS neurons, which is abolished by the inhibition of NR2B-NMDARs. We also report that repeated systemic administration of ethanol causes an NR2B-NMDAR-dependent facilitation of LTP in the DMS. LTP is mediated by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic administration of ethanol, as well as cycles of excessive ethanol consumption and withdrawal, produced a long-lasting increase in synaptic localization of the GluR1 and GluR2 subunits of AMPARs in the DMS. Importantly, we report that inhibition of AMPARs in the DMS attenuates operant self-administration of ethanol, but not of sucrose. Together, our data suggest that aberrant synaptic plasticity in the DMS induced by repeated cycles of ethanol exposure and withdrawal contributes to the molecular mechanisms underlying the development and/or maintenance of excessive ethanol consumption. |
| Databáze: | OpenAIRE |
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