What is known about the action of endocrine disruptors on the immune system?
| Autor: | Estaquier, Jérôme, Blanc, Étienne, Coumoul, Xavier |
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| Přispěvatelé: | Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Coumoul, Xavier |
| Jazyk: | francouzština |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.TOX] Life Sciences [q-bio]/Toxicology
MESH: Humans MESH: Immune System MESH: Environmental Pollutants [SDV.IMM] Life Sciences [q-bio]/Immunology MESH: Hypersensitivity Immune System [SDV.TOX]Life Sciences [q-bio]/Toxicology [SDV.IMM]Life Sciences [q-bio]/Immunology Endocrine Disruptors MESH: Endocrine Disruptors MESH: Polycyclic Aromatic Hydrocarbons |
| Zdroj: | La Revue du Praticien Médecine Générale La Revue du Praticien Médecine Générale, 2021, 71 (7), pp.729-734 |
| ISSN: | 0989-2737 |
| Popis: | International audience; WHAT IS KNOWN ABOUT THE ACTION OF ENDOCRINE DISRUPTORS ON THE IMMUNE SYSTEM? The immune system (innate and adaptive immunity), involves different tissues and cell types to defend the body against external aggressions. This physiological mechanism involves some hormonal systems for its proper functioning. Moreover, new relationships between the immune system and endocrine processes have been recently described. Immunotoxicology is therefore a rapidly expanding field of research. Many environmental pollutants, such as organochlorine pesticides, polycyclic aromatic hydrocarbons or heavy metals, have an impact on the immune response leading either to a deficiency or a hyperactivation (autoimmune disease, allergy). More recently, other endocrine disruptors such as organofluorines are suspected to be immunotoxic. Low-level exposure to pollutants in the general population probably does not explain the development of all the pathologies, but it sentisizes organisms to the development of these pathologies, weakening certain key processes of the immune system. |
| Databáze: | OpenAIRE |
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