The influence of cystathionine on neurochemical quantification in brain tumor in vivo magnetic resonance spectroscopy

Autor: Branzoli, Francesca, Deelchand, Dinesh, Liserre, Roberto, Poliani, Pietro, Nichelli, Lucia, Sanson, Marc, Lehéricy, Stéphane, Marjańska, Małgorzata
Přispěvatelé: Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for Magnetic Resonance Research [Minneapolis] (CMRR), University of Minnesota Medical School, University of Minnesota System-University of Minnesota System, Spedali Civili Hospital [Brescia], University of Brescia, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Branzoli, Francesca
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Magnetic Resonance in Medicine
Magnetic Resonance in Medicine, 2022, 88 (2), pp.537-545. ⟨10.1002/mrm.29252⟩
ISSN: 0740-3194
1522-2594
DOI: 10.1002/mrm.29252⟩
Popis: International audience; Purpose: To evaluate the ability of the PRESS sequence (TE = 97 ms, optimized for 2-hydroxyglutarate detection) to detect cystathionine in gliomas and the effect of the omission of cystathionine on the quantification of the full neurochemical profile.Methods: Twenty-three subjects with a glioma were retrospectively included based on the availability of both MEGA-PRESS and PRESS acquisitions at 3T, and the presence of the cystathionine signal in the edited MR spectrum. In eight subjects, the PRESS acquisition was performed also in normal tissue. Metabolite quantification was performed using LCModel and simulated basis sets. The LCModel analysis for the PRESS data was performed with and without cystathionine.Results: All subjects with glioma had detectable cystathionine levels >1 mM with Cramér-Rao lower bounds (CRLB)
Databáze: OpenAIRE
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