| Autor: |
Parruti, Giustino, Polilli, Ennio, De Socio, Giuseppe Vittorio Luigi, Sozio, Federica, Marconi, Patrizia, Soddu, Viviana, Dalessandro, Margherita, Celesia, Benedetto Maurizio, Pellicanò, Giovanni, Madeddu, Giordano, Vecchiet, Jacopo, Di Masi, Francesco, Mazzotta, Elena, Ursini, Tamara, Martinelli, Canio, Vitiello, Paola, Bonfanti, Paolo, Nigro, Luciano, Mura, Maria Stella Anna, Antinori, Andrea, Ricci, Elena, Manzoli, Lamberto |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Popis: |
Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (pvs 58.0%; pvs 173 ± 246; pvs 29.2%; p=0.02); HAART interruption (7.3% vs 14.6%; p=0.01); proportion reporting optimal adherence (92.2% vs 82.7%, p=0.03). No differences were observed in the prevalence of grade 3-4 WHO toxicities (26.4% vs 26.6%; p=0.9). Multivariate logistic regression showed that being treated in 1998 remained an independent predictor of virological failure after several adjustments, including adherence. Conclusions: Our data from patients not included in clinical trials or cohort studies provide an additional line of evidence that the effectiveness of HAART significantly improved in 2006. Treated patients, however, were significantly older and more frequently late HIV presenters in 2006 than in 1998. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
