| Autor: |
Edwards, L. M., Kemp, G. J., Dwyer, R. M., Walls, J. T., Fuller, H., Smith, S. R., Earnest, C. P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Zdroj: |
Edwards, L M, Kemp, G J, Dwyer, R M, Walls, J T, Fuller, H, Smith, S R & Earnest, C P 2013, ' Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial and their correlates ', Scientific Reports, vol. 3, 1182 . https://doi.org/10.1038/srep01182 |
| DOI: |
10.1038/srep01182 |
| Popis: |
We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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