Albumin–Folate Conjugates for Drug‐targeting in Photodynamic Therapy
| Autor: | Butzbach, Kathrin, Rasse Suriani, Federico Ariel Osvaldo, González, M. Micaela, Cabrerizo, Franco Martín, Epe, Bernd |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Popis: | Photodynamic therapy (PDT) is based on the cytotoxicity of photosensitizers in the presence of light. Increased selectivity and effectivity of the treatment is expected if a specific uptake of the photosensitizers into the target cells, often tumor cells, can be achieved. An attractive transporter for that purpose is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe the synthesis and photobiological characterization of polar β‐carboline derivatives as photosensitizers covalently linked to folate‐tagged albumin as the carrier system. The particles were taken up by KB (human carcinoma) cells within Facultad de Ciencias Exactas |
| Databáze: | OpenAIRE |
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