Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin

Autor:	Lhez, Lucía, Allemandi, Daniel A., Palma, Santiago D., Pappano, Nora B., Debattista, Nora B.
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	abdominal pig skin enhancers probenecid permeation transdermal delivery system Farmacología polycyclic compounds Medicamentos Evaluación de medicamentos urologic and male genital diseases Farmacia female genital diseases and pregnancy complications
Popis:	Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comparatively to lipophilic vehicle (vaseline), carbopol dispersions seen to be more convenient as vehicle for topical administration of probenecid. The results obtained from this study may be helpful in the development of a probenecid transdermal drug delivery system. Colegio de Farmacéuticos de la Provincia de Buenos Aires
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______1329::c060d600c2464cb88e6b25d331180efe http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_2_1.pdf Zobrazit plný text záznamu