Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring

Autor:	Maldonado, Cecilia, Fagiolino, Pietro, Vázquez, Marta, Eiraldi, Rosa, Alvariza, Silvana, Bentancur, Camilo, Álvarez, Pablo
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Anticonvulsivantes Glándulas Salivales Farmacia carbamazepine efflux transporter induction saliva drug levels Monitoreo de Drogas
Popis:	The aim of the present study was to detect efflux transporter induction at salivary glands. Six healthy volunteers were involved. On the first day subjects received a single carbamazepine (CBZ) dose of 400 mg. Couples of salivary samples (first and second fraction, S1 and S2) were collected throughout time after dosing. The following 6 days subjects received 200 mg every twelve hours, and morning pre-dose samples were collected. Colegio de Farmacéuticos de la Provincia de Buenos Aires
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______1329::545f08c2b7b5a3b5a2dcc6affef64445 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_11.pdf Zobrazit plný text záznamu