| Autor: |
PIAZZA, FABRIZIO, Greenberg, SM, Savoiardo, M, GARDINETTI, MARGHERITA, Chiapparini, L, Raicher, I, Nitrini, R, Sakaguchi, H, Brioschi, M, Billo, G, Colombo, A, Lanzani, F, Piscosquito, G, Carriero, MR, Giaccone, G, Tagliavini, F, FERRARESE, CARLO, DI FRANCESCO, JACOPO COSIMO |
| Přispěvatelé: |
Piazza, F, Greenberg, S, Savoiardo, M, Gardinetti, M, Chiapparini, L, Raicher, I, Nitrini, R, Sakaguchi, H, Brioschi, M, Billo, G, Colombo, A, Lanzani, F, Piscosquito, G, Carriero, M, Giaccone, G, Tagliavini, F, Ferrarese, C, DI FRANCESCO, J |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Popis: |
Objective: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is characterized by vasogenic edema and multiple cortical/subcortical microbleeds, sharing several aspects with the recently defined amyloid-related imaging abnormalities (ARIA) reported in Alzheimer's disease (AD) passive immunization therapies. Herein, we investigated the role of anti-amyloid β (Aβ) autoantibodies in the acute and remission phases of CAA-ri. Methods: We used a novel ultrasensitive technique on patients from a retrospective multicenter case-control study, and evaluated the anti-Aβ autoantibody concentration in the cerebrospinal fluid (CSF) of 10 CAA-ri, 8 CAA, 14 multiple sclerosis, and 25 control subjects. Levels of soluble Aβ40, Aβ42, tau, P-181 tau, and APOE genotype were also investigated. Results: During the acute phase of CAA-ri, anti-Aβ autoantibodies were specifically increased and directly correlated with Aβ mobilization, together with augmented tau and P-181 tau. Following clinical and radiological remission, autoantibodies progressively returned to control levels, and both soluble Aβ and axonal degeneration markers decreased in parallel. Interpretation: Our data support the hypothesis that the pathogenesis of CAA-ri may be mediated by a selective autoimmune reaction against cerebrovascular Aβ, directly related to autoantibody concentration and soluble Aβ. The CSF dosage of anti-Aβ autoantibodies with the technique here described can thus be proposed as a valid alternative tool for the diagnosis of CAA-ri. Moreover, given the similarities between ARIA developing spontaneously and those observed during immunization trials, anti-Aβ autoantibodies can be considered as novel potential biomarkers in future amyloid-modifying therapies for the treatment of AD and CAA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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