| Zdroj: |
Holmqvist, V, Roos, L K S, Kjartansdottir, K R, Dunø, M, Hnida, C, Pedersen, I S, Ernst, A, Toft, C L F, Diemer, T, Ingerslev, H J, Pinborg, A & Løssl, K 2019, ' Præimplantationsgenetisk testning for aneuploidi ', Ugeskrift for Laeger, bind 181, nr. 20, V12180849 . < https://ugeskriftet.dk/videnskab/praeimplantationsgenetisk-testning-aneuploidi > |
| Popis: |
This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective. |
