| Autor: |
Kusters, B., Leenders, W.P.J., Wesseling, P., Smits, D., Verrijp, K., Ruiter, D.J., Peters, J.P.W., Kogel, A.J. van der, Waal, R.M.W. de |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Cancer Research, 62, 2, pp. 341-5 |
| Popis: |
Item does not contain fulltext We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mel57, engineered to express recombinant VEGF-A(165), showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
