Effect of kinetic parameters on heterologous protein production: a sysbio approach
| Autor: | Nandy, Subir Kumar, Rattleff, Stig, Thykær, Jette, Eliasson Lantz, Anna |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Nandy, S K, Rattleff, S, Thykær, J & Eliasson Lantz, A 2011, ' Effect of kinetic parameters on heterologous protein production: a sysbio approach ' 6th Danish Conference on Biotechnology and Molecular Biology, Vejle, Denmark, 26/05/2011-27/05/2011, . |
| Popis: | To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition. |
| Databáze: | OpenAIRE |
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