| Autor: |
Garralda, E. (Elena), Geva, R. (Ravit), Ben-Ami, E. (Eytan), Maurice-Dror, C. (Corinne), Calvo, E. (Emiliano), LoRusso, P. (Patricia), Türec, Ö. (Özlem), Niewood, M. (Michelle), Sahin, U. (Ugur), Jure-Kunkel, M. (María), Forssmann, U. (Ulf), Ahmadi, T. (Tahamtan), Melero, I. (Ignacio) |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Agonistic 4-1BB monoclonal antibodies were preclinically validated as promising cancer immunotherapies, both as monotherapy and as potentiators of the activity of PD-(L) 1–blocking agents. However, toxicity and a narrow therapeutic window have hampered their clinical development. DuoBodyPD-L1×4-1BB, a first-in-class, bispecific, next-generation checkpoint immunotherapy, was designed to overcome these limitations by activating T cells through conditional 4-1BB costimulation, while simultaneously blocking the PD-L1 axis. We present preliminary data from the ongoing, first-in-human, open-label, phase I/IIa trial of DuoBody-PD-L1×4-1BB in advanced solid tumors (NCT03917381). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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