| Autor: |
Villarejo-Galende, A. (Alberto), García-Arcelay, E. (Elena), Pinol-Ripoll, G. (Gerard), del Olmo-Rodríguez, A. (Antonio), Viñuela, F. (Félix), Boada, M. (Merce), Franco-Macias, E. (Emilio), Ibáñez de la Pena, A. (Almudena), Riverol-Fernández, M. (Mario), Abizanda-Soler, P. (Pedro), Arroyo, R. (Rafael), Baquero-Toledo, M. (Miquel), Feria-Vilar, I. (Inmaculada), Balasa, M. (Mircea), Berbel, Á. (Ángel), Rodríguez-Rodríguez, E. (Eloy), Vieira-Camposs, A. (Alba), García-Ribas, G. (Guillermo), Rodrigo-Herrero, S. (Silvia), Terrancle, Á. (Ángeles), Prefasi, D. (Daniel), Lleo, A. (Alberto), Maurino, J. (Jorge) |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score >= 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5-1.0. The Quality of Life in Alzheimer ' s Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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