Comparing the patient reported physical function outcome measures in a real-life international cohort of patients with psoriatic arthritis

Autor: Leung, YY, Orbai, AM, de Wit, M, Balanescu, A, Dernis, E, Soubrier, M, Eder, L, Smolen, JS, Coates, LC, Gossec, L, The Reflap Study Group
Zdroj: Journal of Rheumatology.
ISSN: 1499-2752
0315-162X
Popis: Objectives We evaluated the psychometric properties of three patient-reported outcomes (PROMs) to assess the physical function in psoriatic arthritis (PsA). Methods Data available for Health Assessment Questionnaire-disability index (HAQ-DI), Physical component summary score of SF-12 (PCS12) and functional capacity of Psoriatic Arthritic Impact of Disease Instrument (PsAID-FC) from a longitudinal study in 14 countries of consecutive adults with definite PsA with ≥ 2 years of duration. The score distribution, construct validity, responsiveness and thresholds of meaning of the PROMs were evaluated. Results At baseline, 414 subjects (52% male) were analysed. The mean (SD) age and duration of illness were 52.4 (12.5) and 10.9 (8.1) years. Ceiling effects were noted in 31% and 21% of patients for HAQ-DI and PsAID-FC; floor effects were minimal. All three PROMs met a priori hypotheses for construct validity. After a median (IQR) follow-up of 4.1 (2.7) months in 350 patients, 27%, 54% and 18% of patients reported themselves improved, not changed and worse, respectively. Change scores were statistically different for groups for worsening versus no-change for all PROMs. PsAID-FC was more sensitive to change than the other two PROMs. Comparing groups with worsening condition to no-change, the standardized response mean square ratios (SRM2) were for HAQ-DI: 29.9, PCS12: 16.7 and PsAID-FC: 40.1, respectively. Conclusions HAQ-DI, PCS12 and PsAID-FC are valid measures of function for PsA. PsAID-FC, a single question, performed similarly to the other PROMs and may be an additional option to measure PsA-specific physical function.
Databáze: OpenAIRE
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