| Autor: |
Falzone, N, Ackerman, N, De La Fuente Rosales, L, Bernal, M, Peeters, S, Soto, M, Sibson, N, Vallis, K |
| Rok vydání: |
2018 |
| DOI: |
10.1111/imj.13801 |
| Popis: |
Metastasis of breast cancer to the brain presents a pressing therapeutic challenge. Vascular cell adhesion molecule 1 (VCAM‐1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. We have developed a Monte Carlo model representing brain vasculature to evaluate the efficacy of a variety of potential therapeutic nuclides; alpha‐emitters: 149Tb, 211At, 212Pb, 213Bi and 225Ac; beta and Auger electron‐emitters: 90Y, 161Tb and 177Lu, 67Ga, 89Zr, 111In and 124I for targeted radionuclide therapy (TRT). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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