SCALOP-2: A randomised trial of induction GEMABX followed by chemoradiation (high/standard dose radiation) +/-nelfinavir for locally advanced pancreatic cancer: results of the dose-finding component

Autor: Mukherjee, S, Virdee, P, Shaw, R, Bridgewater, J, Radhakrishna, G, Falk, S, Scott-Brown, M, Strauss, V, Brookes, C, Gillmore, R, Patel, N, Tranter, B, Parsons, P, Sebag-Montefiore, S, Hawkins, M, Corrie, P, Maughan, T
Rok vydání: 2018
Popis: The anti-retroviral agent, nelfinavir, demonstrates radiosensitising effects in pre-clinical models of pancreatic cancer. The primary objective of Stage 1 was to establish the maximum tolerated dose (MTD) of nelfinavir combined with capecitabine-chemoradiation (CRT) after gemcitabine+nab-paclitaxel (GEMABX) induction chemotherapy. Other outcomes included overall survival and progression-free survival.
Databáze: OpenAIRE