| Autor: |
Ruizendaal, E, Mens, P, Tahita, M, Geskus, R, Versteeg, I, Traore, M, Lompo, P, Derra, K, Scott, S, Bradley, J, D'Alessandro, U, Tinto, H, Schallig, H |
| Rok vydání: |
2018 |
| DOI: |
10.1111/tmi.12978 |
| Popis: |
Pregnant women are a high risk group forPlasmodium falciparuminfections,which may result in maternalanemia and low birth weight newborns, among other adversebirth outcomes. Intermittent preventive treatment withsulfadoxine-pyrimethamine during pregnancy (IPTp-SP) is widelyimplemented to prevent these negative effects of malaria.However, resistance against SP byP. falciparummay decreaseefficacy of IPTp-SP. Combinations of point mutations in thedhps(codons A437, K540) anddhfrgenes (codons N51, C59,S108) ofP. falciparumare associated with SP resistance.AimTo study the prevalence of SP resistance mutations wasdetermined amongP. falciparumfound in pregnant women andthe general population (GP) from Nanoro, Burkina Faso and theassociation of IPTp-SP dosing and other variables withmutations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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