| Autor: |
Kelly, C, Tinago, W, Alber, D, Hunter, P, Luckhurst, N, Connolly, J, Arrigoni, F, Abner, AG, Kamngona, R, Sheha, I, Chammudzi, M, Jambo, K, Mallewa, J, Rapala, A, Heyderman, RS, Mallon, PWG, Mwandumba, H, Walker, AS, Klein, N, Khoo, S |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Popis: |
Background Inflammation drives vascular dysfunction in HIV, but in low-income settings causes of inflammation are multiple, and include infectious and environmental factors. We hypothesised that patients with advanced immunosuppression could be stratified into inflammatory phenotypes that predicted changes in vascular dysfunction on ART. Methods We recruited Malawian adults with CD4Results 211 HIV-positive participants grouped into three clusters of inflammatory marker profiles representing 51 (24%) (cluster-1), 153 (73%) (cluster-2) and 7 (3%) (cluster-3) individuals. Cluster-1 showed markedly higher CD4 and CD8 T-cell expression of HLADR and PD1 vs cluster-2 and cluster-3 (all pConclusions Two inflammatory clusters were identified: one defined by high T-cell PD1 expression and another by a hyper-inflamed profile and increases in cfPWV on ART. Further clinical characterisation of these inflammatory phenotypes could help target vascular dysfunction interventions to those at highest risk. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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