Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
| Autor: | Mitchell, J, Kirkby, NS |
|---|---|
| Přispěvatelé: | British Heart Foundation |
| Rok vydání: | 2018 |
| Předmět: |
Science & Technology
PROSTAGLANDIN SYNTHASE SODIUM-NITROPRUSSIDE NONSTEROIDAL ANTIINFLAMMATORY DRUGS ACTIVATED RECEPTOR-BETA/DELTA EPAC PROTEINS CONCISE GUIDE RANDOMIZED-TRIAL cardiovascular system lipids (amino acids peptides and proteins) Pharmacology & Pharmacy NITRIC-OXIDE SYNTHASE 1115 Pharmacology and Pharmaceutical Sciences MESSENGER-RNA Life Sciences & Biomedicine PLATELET |
| Popis: | Eicosanoids represent a diverse family of lipid mediators with fundamental roles in controlling physiology and disease. Within the eicosanoid super family are prostanoids, which are specifically derived from arachidonic acid by the enzyme cyclooxygenase (C OX) . COX has two isoforms; COX - 1 and COX - 2. COX - 2 is the therapeutic target for the nonsteroidal anti - inflammatory drug (NSAID) class of pain medications. Of the prostanoids, prostacyclin, first discovered by Sir Professor John Vane in 1976 , remains amongs t the best studied and retains an impressive pedigree as on e the bodies fundamental cardiovascular protective pathways. Since this time , we have learnt much about how eicosanoids, COX enzymes and prostacyclin function in the cardiovascular system which has allowed us to, for example, harness the power of prostacyclin as therapy to treat pulmonary arterial hypertension and peripheral vascular disease. However, there remain many unanswer ed questions in our basic understanding of the pathways and how they can be used to improve human health. Perhaps the most important and controversial outstanding question in the field remains ; ‘ how do NSAIDs produce their much publicized cardiovascular si de effects ?’ This review summarises the history, bio logy and cardiovascular function of key eicosanoids with particular focus on prostacyclin and other COX products and discusses how our knowledge of these pathways can applied in future drug discovery and be used to explain the cardiovascular side effects of NSAIDs. |
| Databáze: | OpenAIRE |
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