HIV-associated M. tuberculosis blood stream infection is under-diagnosed by a single blood culture
| Autor: | Barr, DA, Kerkhoff, AD, Schuttz, C, Ward, AM, Davies, GR, Wilkinson, RJ, Meintjes, G |
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| Přispěvatelé: | Wellcome Trust |
| Rok vydání: | 2018 |
| Předmět: |
PROTOCOL
BACTEREMIA Science & Technology human immunodeficiency virus SEPSIS Mycobacterium tuberculosis ADULTS 11 Medical And Health Sciences 06 Biological Sciences bacterial infections and mycoses blood culture Microbiology PREVALENCE TRIAL 07 Agricultural And Veterinary Sciences human activities Life Sciences & Biomedicine |
| Popis: | We assessed the additional diagnostic yield for Mycobacterium tuberculosis bloodstream infection (BSI) by doing more than one tuberculosis (TB) blood culture from HIV-infected inpatients. In a retrospective analysis of two cohorts based in Cape Town, South Africa, 72/99 (73%) patients with M. tuberculosis BSI were identified by the first of two blood cultures during the same admission, with 27/99 (27%; 95% confidence interval [CI], 18 to 36%) testing negative on the first culture but positive on the second. In a prospective evaluation of up to 6 blood cultures over 24 h, 9 of 14 (65%) patients with M. tuberculosis BSI had M. tuberculosis grow on their first blood culture; 3 more patients (21%) were identified by a second independent blood culture at the same time point, and the remaining 2 were diagnosed only on the 4th and 6th blood cultures. Additional blood cultures increase the yield for M. tuberculosis BSI, similar to what is reported for nonmycobacterial BSI. |
| Databáze: | OpenAIRE |
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