Immediate and midterm cardiac remodelling following surgical pulmonary valve replacement in adults with repaired tetralogy of fallot: a prospective cardiovascular magnetic resonance and clinical study
| Autor: | Heng, E, Gatzoulis, M, Uebing, A, Sethia, B, Uemura, H, Smith, G, Diller, G, McCarthy, K, Ho, SY, Li, W, Wright, P, Spadotto, V, Kilner, PJ, Oldershaw, P, Pennell, DJ, Shore, DF, Babu-Narayan, SV |
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| Přispěvatelé: | British Heart Foundation |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cardiac & Cardiovascular Systems IMPACT OUTFLOW TRACT DYSFUNCTION PREOPERATIVE THRESHOLDS ventricular remodeling 1117 Public Health and Health Services pulmonary valve AGE magnetic resonance imaging Humans tetralogy of Fallot 1102 Cardiorespiratory Medicine and Haematology Heart Valve Prosthesis Implantation OUTCOMES Science & Technology ARRHYTHMIA AREA DEATH Stroke Volume 1103 Clinical Sciences RELIEF Peripheral Vascular Disease Cardiovascular System & Hematology Heart Valve Prosthesis Cardiovascular System & Cardiology Female IMPLANTATION Life Sciences & Biomedicine Follow-Up Studies |
| Popis: | Background: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm post-PVR changes and predictors of reverse remoeling. Methods: Fifty-seven patients with repaired tetralogy of Fallot (age ≥16 y; mean age, 35.8±10.1 y; 38 male) undergoing PVR were prospectively recruited for cardiovascular magnetic resonance performed before PVR (pPVR), immediately after PVR (median, 6 d), and midterm after PVR (mPVR; median, 3 y). Results: There were immediate and midterm reductions in indexed RV end-diastolic volumes and RV end-systolic volumes (RVESVi) (indexed RV end-diastolic volume pPVR versus immediately after PVR versus mPVR, 156.1±41.9 versus 104.9±28.4 versus 104.2±34.4 mL/m2; RVESVi pPVR versus immediately after PVR versus mPVR, 74.9±26.2 versus 57.4±22.7 versus 50.5±21.7 mL/m2; P |
| Databáze: | OpenAIRE |
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