| Autor: |
Crimmin, MR, Coates, G, Bakewell, C, Ward, B, White, A |
| Přispěvatelé: |
The Royal Society, Commission of the European Communities |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
sp3C-F bonds of fluoroalkanes (7 examples; 1o, 2o and 3o) undergo addition to a low-valent Mg-Mg species generating reactive organomagnesium reagents. Further reactions with a series of electrophiles results in a net C-F to C-B, C-Si, C-Sn or C-C bond transformation (11 examples, diversity). The new reactivity has been exploited in an unprecedented one-pot magnesium-mediated coupling of sp3C-F and sp2C-F bonds. Calculations suggest that the sp3C-F bond activation step occurs by frontside nucleophilic attack of the Mg-Mg reagent on the fluoroalkane. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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