| Autor: |
Bunjun, R, Riou, C, Soares, AP, Thawer, N, Müller, TL, Kiravu, A, Ginbot, Z, Oni, T, Goliath, RT, Kalsdorf, B, Von Groote-Bidlingmaier, F, Hanekom, W, Walzl, G, Wilkinson, RJ, Burgers, W |
| Přispěvatelé: |
Wellcome Trust |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
HIV-1 infection substantially increases the risk of developing tuberculosis (TB). There is extensive depletion of Mycobacterium tuberculosis (M.tuberculosis)-specific CD4+ T cells in blood in early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4 destruction, we investigated M.tuberculosis-specific responses in bronchoalveolar lavage (BAL), in persons with latent TB infection and untreated HIV-1 co-infection with preserved CD4 counts. M.tuberculosis-specific CD4+ cytokine responses (IFN-, TNF- and IL-2) were discordant in frequency and function between BAL and blood. Responses in BAL were 15-fold lower in HIV-infected compared to uninfected persons (p=0.048), whilst blood responses were 2-fold lower (p=0.006). However, an increase in T cells in the airways in HIV-infected persons resulted in the overall number of M.tuberculosis-specific CD4+ cells in BAL being similar. Our study highlights the important insights gained from studying TB immunity at the site of disease during HIV infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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