| Autor: |
Amin, A, Neophytou, C, Thein, S, Martin, N, Alamshah, SA, Spreckley, E, Bloom, S, Murphy, KG |
| Přispěvatelé: |
Biotechnology and Biological Sciences Research Council (BBSRC), Medical Research Council (MRC) |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Objective The satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it has been shown that oral L‐arginine acts as a GLP‐1 secretagogue both in vitro and in vivo in rodents. Here, the effect of L‐arginine on gut hormone release in humans was investigated. Methods The hypothesis was tested in two separate studies. The first study assessed the tolerability of oral L‐arginine in healthy human subjects. The second study assessed the effect of oral L‐arginine on gut hormone release following an ad libitum meal. Subjects were given L‐arginine, glycine (control amino acid), or vehicle control in a randomized double‐blind fashion. Results At a dose of 17.1 mmol, L‐arginine was well tolerated and stimulated the release of plasma GLP‐1 (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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