Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy: a new model of autoimmune heart disease
| Autor: | Hasham, MG, Baxan, N, Stuckey, D, Dent, O, Branca, J, Perkins, BRA, Duffy, T, Hameed, TS, Stella, SE, Bellahcene, M, Schneider, MD, Harding, SE, Rosenthal, N, Sattler, S |
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| Přispěvatelé: | British Heart Foundation, Wellcome Trust, Medical Research Council (MRC) |
| Rok vydání: | 2017 |
| Předmět: |
Toll-like receptor 7/8
Science & Technology Resiquimod PATHOGENESIS Dilated cardiomyopathy Autoimmunity Cell Biology CARDIAC INVOLVEMENT 11 Medical And Health Sciences Heart disease DERMATOMYOSITIS 06 Biological Sciences RHEUMATOID-ARTHRITIS Myocarditis MICE POLYMYOSITIS B-CELLS Pathology LUPUS-ERYTHEMATOSUS T-CELLS AUTOANTIBODIES Life Sciences & Biomedicine Model Developmental Biology |
| Popis: | Systemic autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here we characterize immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the TLR-7/8 agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity. |
| Databáze: | OpenAIRE |
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