A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring
| Autor: | Pagkalos, I, Rogers, M, Boutelle, MG, Drakakis, EM |
|---|---|
| Přispěvatelé: | Wellcome Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0306 Physical Chemistry (incl. Structural)
Traumatic Brain Injury Science & Technology Chemical Physics Chemistry Physical Physics CONTINUOUS ONLINE MICRODIALYSIS Physics Atomic Molecular & Chemical DEPRESSION LACTATE Neurophysiological Monitoring GLUCOSE Chemistry Electricity Physical Sciences Brain Injuries Traumatic 0202 Atomic Molecular Nuclear Particle and Plasma Physics Application Specific Integrated Chip for Neurochemical Monitoring Humans 0307 Theoretical and Computational Chemistry SPREADING DEPOLARIZATIONS HUMAN CEREBRAL-CORTEX |
| Popis: | This paper presents the first application specific integrated chip (ASIC) for the monitoring of patients who have suffered a Traumatic Brain Injury (TBI). By monitoring the neuralphysiological (ECoG) and neurochemical (glucose, lactate and potassium) signals of the injured human brain tissue, it is possible to detect spreading depolarisations, which have been shown to be associated with poor TBI patient outcome. This paper describes the testing of a new 7.5mm2 ASIC fabricated in the commercially available AMS 0.35μm CMOS technology. The ASIC has been designed to meet the demands of processing the injured brain tissue's ECoG signals, recorded by means of depth or brain surface electrodes, and neurochemical signals, recorded using microdialysis coupled to microfluidics-based electrochemical biosensors. The potentiostats use switched-capacitor charge integration to record currents with 100fA resolution, and allow automatic gain changing to track the falling sensitivity of a biosensor. This work supports the idea of a "behind the ear" wireless microplatform modality, which could enable the monitoring of currently non-monitored mobile TBI patients for the onset of secondary brain injury. |
| Databáze: | OpenAIRE |
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