| Autor: |
Kallis, C, Maslova, E, Morgan, A, Sinha, I, Roberts, G, Van der Valk, R, Quint, J, Tran, T |
| Rok vydání: |
2023 |
| Popis: |
Background: Asthma-related burden remains poorly characterised in children in the United Kingdom (UK). We quantified recent trends in asthma prevalence and burden in a UK population-based cohort (1‒17-year-olds). Methods: The Clinical Practice Research Datalink Aurum database (2008‒2018) was utilised to assess annual asthma incidence and prevalence in 1‒17-year-olds and pre-school wheeze in 1‒5-year-olds, stratified by gender and age. During the same period, annual asthma exacerbation rates were assessed in those with either a diagnosis of pre-school wheeze or asthma. Results: Annual asthma incidence rates decreased by 51% from 1403.4 (95% confidence interval 1383.7‒1423.2) in 2008 to 688.0 (676.3‒699.9) per 105 person-years (PYs) in 2018, with the most pronounced decrease observed in 1‒5-year-olds (decreasing by 65%, from 2556.9 [2509.8‒2604.7] to 892.3 [866.9‒918.3] per 105 PYs). The corresponding decreases for the 6‒11- and 12‒17-year-olds were 36% (1139.9 [1110.6‒1169.7] to 739.9 [720.5‒759.8]) and 20% (572.3 [550.4‒594.9] to 459.5 [442.9‒476.4]) per 105 PYs, respectively. The incidence of pre-school wheeze decreased over time and was slightly more pronounced in the 1‒3-year-olds than in the 4-year-olds. Prevalence of asthma and pre-school wheeze also decreased over time, from 18.0% overall in 2008 to 10.2% in 2018 for asthma. Exacerbation rates increased over time from 1.33 (1.31‒1.35) per 10 PYs in 2008 to 1.81 (1.78‒1.83) per 10 PYs in 2018. Conclusion: Paediatric asthma incidence decreased in the UK since 2008, particularly in 1– 5-year-olds; this was accompanied by a decline in asthma prevalence. Pre-school wheeze incidence also decreased in this age group. However, exacerbation rates have been increasing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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