Synthesis of the marine natural product N-alpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids

Autor: Lindel, T., Hochgürtel, M., Assmann, M., Köck, Matthias
Rok vydání: 2000
Předmět:
Zdroj: EPIC3Journal of Natural Products, 63, pp. 1566-1569
Popis: Lysine is proposed as an alternative biosynthetic precursor of the pyrrole-imidazole alkaloids frequently found in marine sponges. As a putative key intermediate, the natural product N-alpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine (1) from the sponge Agelas wiedenmayeri was synthesized in the solid phase starting from the Fmoc/Pmc-protected L-homoarginine and in solution starting from readily available L-lysine methyl ester.
Databáze: OpenAIRE