Potpuni patološki odgovor nakon neoadjuvantne kemoradioterapije lokalno uznapredovalog karcinoma rektuma
| Autor: | Miličević, Ozana, Trkulja, Ines, Matijević, Andrija, Ćurt, Loris, Sesar, Patricija, Solak, Meliha, Ramić, Snježana, Kirac, Iva |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Libri Oncologici : Croatian Journal of Oncology Volume 50 Issue 2-3 |
| ISSN: | 2584-3826 0300-8142 |
| Popis: | Background: The prognosis of rectal cancer has improved with neoadjuvant treatment for locally advanced disease. Twenty percent of patients respond to treatment with complete pathological regression, which is clinically estimated with magnetic resonance imaging. Aim: describe the properties of the pathological complete response group of patients at our institution Materials and methods: All selected patients received LCCRT at the University Hospital for Tumors Sestre milosrdnice University Hospital Center, Zagreb, between January 2014 and December 2019 and were later surgically treated at the same facility. Results: We identified 23 patients with complete pathological responses, of which, despite surgery, seven progressed. We recorded a higher proportion of female patients in that group and younger age of onset. MRI preoperatively was not yet predictive of a complete pathological response. Conclusion: The proportion of patients with a complete pathological response is 16% in this cohort. All patients underwent surgery but did not receive consolidating therapy. About 30% progressed during the observed period. Uvod: Prognoza raka rektuma poboljšana je neoadjuvantnim liječenjem lokalno uznapredovale bolesti. Dvadeset posto pacijenata reagira na liječenje potpunom patološkom regresijom, što se klinički procjenjuje magnetskom rezonancijom(MR). Cilj: opisati svojstva skupine pacijenata s patološkim potpunim odgovorom u našoj ustanovi Materijali i metode: Svi odabrani pacijenti primili su LCCRT u KBC-u Sestre milosrdnice, Zagreb, između siječnja 2014. i prosinca 2019. te su kasnije kirurški liječeni u istoj ustanovi. Rezultati: Identificirali smo 23 pacijenta s potpunim patološkim odgovorom, od kojih je, unatoč operaciji, sedam imalo progresiju bolesti. U toj skupini bilježimo veći udio bolesnica i mlađu dob pri dijagnozi. Magnetska rezonanca prije operacije nije bila pouzdan pokazatelj potpunog patološkog odgovora. Zaključak: Udio pacijenata s potpunim patološkim odgovorom je 16% u ovoj kohorti. Svi pacijenti su operirani, ali nisu primili konsolidirajuću kemoterapiju. Oko 30% je imalo progresiju bolesti tijekom promatranog razdoblja. |
| Databáze: | OpenAIRE |
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