Učinak pripravaka ginka na agregaciju trombocita u štakora

Autor: Marija Skoko, Domagoj Đikić, Ivan Čolić, Maja Tomičić, Tiha Vučemilo
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Libri Oncologici : Croatian Journal of Oncology
Volume 45
Issue 1
ISSN: 2584-3826
0300-8142
Popis: Ginkgo biloba is an herbal remedy can be found as an ingredient of many dietary supplements. Ginkgo contains different biologically active compounds that can inhibit platelet aggregation. Prolonged platelet aggregation can have apositive effect on the cardiovascular system in cancer patients undergoing chemotherapy, but in oncological surgery (in particular major abdominal, gynecological, and operations with reconstructions) it can increase risk of bleeding.Consequently in these patients there is a need for perioperative assess of the impact of ginkgo on platelet aggregation. In this study we investigated the eff ect of diff erent supplements on platelet aggregation available on the free market which by declaration are containing ginkgo extract alone or in combination with other plants. The study was conducted on 24 male rats Y59, divided into 4 groups, depending on the herbal food supplements which was used for treatment. Platelet aggregation was determined on Multiplate analyzer, impedance aggregometry. Prolonged platelet aggregation was measured in groups b ginkgo (P=0.025), c vulkan (P=0.004), d GOI (P=0.035) compared to control group when it was used ADP as agonist. Platelet aggregation where it was used collagen as agonist showed no statistically signifi cant diff erence between groups.
Ekstrakt biljke Ginkgo biloba može se naći kao sastojak brojnih dodataka prehrani te imamo još registrirane biljne lijekove na bazi Ginka. Ginko sadrži različite biološki aktivne tvari koje mogu djelovati na inhibiciju agregacije trombocita što može pozitivno ali i negativno djelovati na kardiovaskularni sustav u onkoloških bolesnika na kemoterapiji, a kod onkoloških operacija (naročito većih abdominalnih, ginekoloških, te operacija s rekonstrukcijom) povećan je rizik od krvarenja, te je kod takvih bolesnika potrebno perioperativno procijeniti utjecaj na agregaciju u slučaju korištenja pripravaka ginka. U ovom radu istražili smo učinak ginka i raznih suplemenata koji sadrže ginkgo na agregaciju trobocita. Ispitivanje je vršeno na 4 skupine po 6 muških štakora soja Y59, od kojih je jedna bila kontrola, a ostale tri su dobivale ginko i ginko s različitim biljnim dodacima. Agregacija trombocita mjerena je na Multiplate analizatoru, impedancijskom agregometru. Agregacija trombocita bila je produžena gdje smo u testiranju koristili ADP kao agonist u sve tri tretirane skupine u odnosu na kontrolu, skupini b ginkgo (P=0.025), c vulkan (P=0.004) i d GOI (P=0,035), dok agregacija s kolagenom kao agonistom nije bila statistički značajno produžena.
Databáze: OpenAIRE
Externí odkaz: