Comparison of Osteoimmunological and Microbiological Parameters of Extra Short and Longer Implants Loaded in the Posterior Mandible: A Split Mouth Randomized Clinical Study

Autor: Karci, Bilge, Oncu, Elif
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Acta stomatologica Croatica : International journal of oral sciences and dental medicine
Volume 55
Issue 3
ISSN: 1846-0410
0001-7019
Popis: Objectives: This study aimed to evaluate the levels of TNF-α, PGE2, RANKL, RANK, OPG, the markers of periimplant bone loss in peri-implant crevicular fluid obtained around standard and extra short implants. Moreover, the levels of putative oral pathogens were investigated in the submucosal biofilm samples. Material and Methods: The implants were divided into two groups according to their lengths: standard (≥8 mm) and extra short (4 mm). A total of 60 implants were researched in 30 patients. The probing depth (PD), clinical attachment level (CAL), presence of bleeding on probing (BOP), 3-year survival rate (CSR), and bone loss (BL) were measured. Results: No statistically significant difference was found in the values of PD, CAL, BOP, CSR, and BL between the groups (P> 0.05). Total amounts of PGE2, TNF-α, RANKL, RANK, OPG, and RANKL/OPG were not statistically significantly different between the groups (P> 0.05). The abundance of F. nucleatum, T. forsythia, P. intermedia, P. gingivalis, S. oralis and T. denticola was compared between the groups and the results were not statistically significant (P> 0.05). Conclusion: The results of this study suggested that PGE2, TNF-α, RANKL, RANK, OPG, and RANKL/OPG in PICF, as well as microbiological parameters in submucosal biofilms, were similar between standard (≥8 mm) and extra short (4 mm) implants. Therefore, the implant length does not seem to influence the bone loss, levels of osteoimmunological and microbiological markers in the peri-implant tissues and survival rates.
Cilj: Željelo se procijeniti razine TNF-α, PGE2, RANKL-a, RANK-a i OPG-a, biljega gubitka kosti oko implantata u periimplantatnoj krevikularnoj tekućini oko standardnih i ekstremno kratkih implantata. Nadalje, ispitivane su i razine mogućih oralnih patogena u uzorcima submukoznog biofilma. Materijal i metoda: Implantati su podijeljeni u dvije skupine prema dužini – na standardne (≥ 8mm) i ekstremno kratke (4 mm). Ispitano je ukupno 60 implantata ugrađenih kod 30 sudionika. Mjerena je dubina sondiranja (PD), klinička razina pričvrstka (CAL), krvarenje pri sondiranju (BOP), trogodišnja stopa preživljenja (CSR) i gubitak kosti (BL). Rezultati: Između skupina nije bilo statistički značajne razlike u vrijednostima PD-a, CAL-a, BOP-a, CSR-a i BL-a (p > 0,05). Ukupne vrijednosti TNF-α, PGE2, RANKLa, RANK-a i OPG-a te omjer RANKL/OPG nisu bili statistički značajni između skupina (p > 0,05). Brojnost mikroorganizama F. nucleatum, T. forsythia, P. intermedia, P. gingivalis, S. oralis i T. denticola također je uspoređena, no rezultati nisu bili statistički značajni (p > 0,05). Zaključak: Prema rezultatima dobivenima u ovom istraživanju vrijednosti TNF-α, PGE2, RANKL-a, RANK-a i OPG-a te omjer RANKL/OPG u periimplantatnoj krevikularnoj tekućini i mikrobiološki parametri u submukoznom biofilmu slični su i oko standardnih (≥ 8 mm) i oko ekstremno kratkih (4 mm) implantata. Zato se čini da dužina implantata ne utječe na gubitak kosti i razinu osteoimunoloških i mikrobioloških biljega u periimplantatnom tkivu te na stopu preživljenja.
Databáze: OpenAIRE
Externí odkaz: