Pentadecapeptide BPC 157 counteracts portal hypertension, caval hypertension and aortal hypotension with suprahepatic occlusion of inferior caval vein in rats

Autor: Slaven Gojković, Hrvoje Vraneš, Zoya Jelovečki – Dokić, Oliver Marcel Koltay, Will Migo, Dominik Malekinušić
Jazyk: angličtina
Rok vydání: 2019
Předmět:
body regions
surgical procedures
operative
We introduce pentadecapeptide BPC 157 as the therapy of the hemodynamic disturbances in the prolonged suprahepatic occlusion of inferior caval vein (ICV) in rats mimicking Budd-Chiari syndrome. Previously
in rats with portal triad obstruction BPC 157 beneficially increased vessels branching in the intestinal serosa and counteracted intestinal lesions. It also counteracts free radical formation
and most importantly
counteracts portal hypertension and caval hypotension. In deeply anesthetized and laparatomized rats that have suprahepatic occlusion of ICV
the recording lasted 5 minutes with a cannula (assessed in one minute intervals) connected to a pressure transducer
inserted into the portal vein
inferior caval vein and abdominal aorta at the level of bifurcation
at 24 h or 48 h of ligation time. Medication (BPC 157)
or saline (controls)) was applied in rats with suprahepatic occlusion of ICV
as an abdominal bath or as an intragastric application
at 24 h or 48 h reperfusion time. Assessment of portal
caval and aortal pressure showed huge portal hypertension and more caval hypertension along with mild aortic hypotension. Contrarily
when BPC 157 was given in those circumstances of the portal and caval hypertension
and arterial hypotension
these disturbances were marked counteracted. Thus
suprahepatic ICV occlusion provides high caval hypertension
even elevated in comparison to portal hypertension
and thereby
spontaneous decompression of the portal system can hardly be expected by a portocaval shunt. BPC 157
may be a consistent therapy solution
cardiovascular system
cardiovascular diseases
circulatory and respiratory physiology
Zdroj: Liječnički vjesnik
Volume 141
Issue suppl.1
ISSN: 1849-2177
0024-3477
Popis: Portal hypertension, aortal hypotension, caval hypertension
Databáze: OpenAIRE
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