Synthesis of Aminohydroxy Acids from α-Amino Acids. Amino Acids XXXVII
| Autor: | K. Balenović, D. Cerar, N. Bregant |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1956 |
| Zdroj: | Croatica Chemica Acta Volume 28 Issue 4 |
| ISSN: | 1334-417X 0011-1643 |
| Popis: | A synthesis is described of the optically active a-hydroxy-B- amino acids VII, and of B-hydroxy-y-amino acids VIII from optically active a-amino acids. a-Hydroxy - B-amino acids were prepared from B-phthalimido-a oxo acids IV. The preparation of these oxo acids started from phthalimido diazoketones obtained from a-amino acids which were converted to bromoketones, and then converted using Krohnke's synthesis through the pyridinium salts V into substituted nitriles VI. Hydrolysis of these nitriles afforded optically active B-phthalimido-a-oxo acids IV, which were converted through catalytic hydrogenation into B-phthalimido-a-hydroxy acids, and thesefurther, by hydrolysis with hydriodic and acetic acids, into a-hydroxy-B-amino acids VII. |
| Databáze: | OpenAIRE |
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