Autoimuni poliglandularni sindrom tip II. - prikaz slučaja
| Autor: | Branko Bečejac, Marijo Bekić, Mira Misjak, Miljenko Solter, Milan Vrkljan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
endocrine system
Poliendokrinopatije autoimune dijagnostika Addisonova bolest etilogija Tiroiditis automuni dijagnostika Prikaz slučaja endocrine system diseases Polyendocrinopathies autoimmune diagnosis Addison’s disease etiology Thyroiditis autoimmune diagnosis Case report hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta clinica Croatica Volume 40 Issue 4 |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | Presentation is made of a 41-year-old man with Addison’s disease and coexistent Hashimoto’s thyroiditis and hypothyroidism. The two diseases are presumed to be of autoimmune etiology and to manifest as part of the autoimmune polyglandular syndrome type II, as also suggested by tissue typing for HLA B8 locus. Inadequate TSH suppression with standard levothyroxine substitution therapy for a one-year period or with higher substitution doses of 200 mg during TRH stimulation, with FT4 which showed no major increase but remained within lower normal limits, indicated partial hypophyseal resistance to thyroxin and/or possible development of autoantibodies to peripheral thyroid hormones. Prikazan je 41-godišnji bolesnik s Addisonovom bolešću i pridruženim Hashimotovim tireoiditisom i hipotireozom. Za pretpostaviti je da su ove dvije bolesti autoimune etiologije i da se javljaju u okviru autoimunog poliglandularnog sindroma tipa II., na što upućuje i tipizacija tkiva u smislu HLA B8 lokusa. Nedovoljna supresija TSH standardnom nadomjestnom terapijom levotiroksinom kroz dulje vremensko razdoblje od godinu dana, kao i većim nadomjestnim dozama od 200 mg tijekom stimulacije TRH, uz FT4 koji se nije značajnije povisio, nego je ostao u nižem normalnom rasponu, ukazivala je na djelomičnu rezistenciju hipofize na tiroksin i/ili mogućnost razvoja autoantitijela na periferne hormone štitnjače. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|