Sarkomatoidni karcinom pleure – prikaz slučaja
| Autor: | Mile Bogdan, Dražena Srdić, Sanja Pleština, Luka Brčić |
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| Jazyk: | chorvatština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Medicina Fluminensis : Medicina Fluminensis Volume 50 Issue 1 |
| ISSN: | 1848-820X 1847-6864 |
| Popis: | Cilj: Prikazati slučaj 57-godišnje pacijentice koja je upućena na Kliniku zbog sumnje na mezoteliom pleure te istaknuti važnost histološke analize tumora. Prikaz slučaja: Radiološkom obradom toraksa vidljive su brojne solidne, dobro vaskularizirane tumorske formacije na pleuri lijevo uz opsežan pleuralni izljev u lijevom prsištu. Fiberbronhocitološkom obradom nisu nađene maligne stanice, a citološki nalaz pleuralnog punktata odgovarao je limfocitnom tipu izljeva, bez malignih stanica. Patohistološki nalaz bioptata pleure pokazao je slabo diferencirani sarkomatoidni karcinom. Provedena je citostatska kemoterapija prema MAID protokolu (Mesna, doksorubicin, ifosfamid, dakarbazin). Nakon četiri ciklusa kemoterapije radiološki je došlo do djelomične regresije pleuralnog izljeva. Zaključak: Sarkomatoidni karcinom pleure vrlo je rijedak tumor toraksa. Predstavlja diferencijalno-dijagnostički problem, jer može oponašati druge bolesti, osobito mezoteliom. Dijagnoza je postavljena patohistološkom i imunohistokemijskom analizom tumora. Izbor liječenja je sustavna citostatska kemoterapija, a prognoza je lošija nego kod karcinoma pluća. Aim: To report the case of a 57-year-old patient, who came with suspicion of pleural mesothelioma, and to emphasise the importance of histological analysis of tumour. Case report: Chest CT scan revealed numerous solid well-vascularized tumour formations of the left pleura with large pleural effusion. Fiber-broncho-cytological processing revealed no malignant cells, whereas the cytological analysis of pleural punctate corresponded to the lymphocytic type of effusion with no malignant cells. Histopathological analysis confirmed poorly differentiated sarcomatoid carcinoma. The patient was treated with cytostatic chemotherapy according to MAID protocol (Mesna, doxorubicin, ifosfamide, and dacarbazine). After four chemotherapy cycles, pleural effusion partially regressed. Conclusion: Sarcomatoid carcinoma of the pleura is a very rare tumour of thorax. It represents a differential diagnostic problem because it can imitate other diseases, especially mesothelioma. In the presented case, the diagnosis was made using histopathological and immunohistochemical analysis of tumour. The choice of treatment is systematic cytostatic chemotherapy, and the prognosis is much better with lung cancer |
| Databáze: | OpenAIRE |
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