Dynamics of concentrations of Ca, Mg, P, and glucose after intravenous administration of complex solutions of calcium, magnesium, phosphorus, and glucose to rabbits

Autor: Saulius Dabužinskas, Gintaras Daunoras, Algimantas Matusevičius
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Veterinarski arhiv
Volume 74
Issue 2
ISSN: 1331-8055
0372-5480
Popis: Presented in this article are data of pre-clinical rabbit trials using calcium borogluconate and calcium glycerophosphate injection solution of new composition containing phosphorus and magnesium salts, glucose and caffeine. The dynamics of concentrations of Ca, Mg, P, and glucose in the blood serum were studied. This data was then compared with that of the commercial veterinary medicinal product. When rabbits received an intravenous injection of 21 mg/kg of total calcium, a statistically significant increase in calcium concentration in the blood serum was recorded after 15 and 60 min. It was established that when the inorganic phosphorus contained in sodium dihydrophosphate is administered intravenously it has superior bioavailability than inorganic phosphorus contained in calcium glycerophosphate. Pure phosphorus (7.9 mg/kg) contained in the injected sodium dihydrophosphate salt produced a statistically larger increase in inorganic phosphorus concentration after 15 and 60 min. compared to 10 mg/kg of pure phosphorus contained in the calcium glycerophosphate salt injected. Complex injection solution A1 containing calcium borogluconate, sodium dihydrophosphate, and magnesium chloride, were distinguished by the best bioavailability, and compared to the control solution produced the greatest and longest-lasting increase in concentrations of calcium, magnesium, and inorganic phosphorus in blood serum of rabbits. Newly created complex solutions A1 and A2 of different compositions are suitable for parenteral use and are well tolerated by rabbit organism, and upon intravenous injection produce an increase in total calcium, magnesium, and inorganic phosphorus in the rabbit blood which lasts for several hours.
U radu su iznijeti podaci pretkliničkih istraživanja na kunićima koristeći injekcijske otopine kalcijeva boroglukonata i kalcijeva glicerofosfata u novoj smjesi s fosfornim i magnezijevim solima, glukozom i kofeinom. Istraživano je kretanje koncentracije Ca, Mg, P i glukoze u krvnom serumu. Rezultati su potom uspoređivani s rezultatima polučenim upotrebom komercijalnih veterinarsko medicinskih proizvoda. Statistički značajan porast koncentracije kalcija u krvnom serumu zabilježen je 15-60 minuta nakon intravenske injekcije ukupnog kalcija u količini 21 mg/kg. Potvrđeno je da neorganski fosfor sadržan u natrijevu dihidrofosfatu primijenjenom intravenski ima bolju bioraspoloživost od neorganskog fosfora sadržanog u kalcijevu glicerofosfatu. Čisti fosfor (7,9 mg/ kg) sadržan u injiciranoj soli natrijeva dihidrofosfata doveo je nakon 15 do 60 minuta do statistički većeg povečanja koncentracije neorganskog fosfora u usporedbi s 10 mg/kg čistog fosfora sadržanog u danoj soli kalcijeva glicerofosfata. Sastavljena injekcijska otopina A1 koja je sadržavala kalcijev boroglukonat, natrijev dihidrofosfat i magnezijev klorid odlikovala se najboljom bioraspoloživošću i u usporedbi s kontrolnom otopinom potaknula najveće i dugotrajno povećanje koncentracije kalcija, magnezija i neorganskog fosfora u krvnom serumu kunića. Pripravljene otopine A1 i A2 različitog sastava prikladne su za parenteralnu upotrebu. Kunići ih dobro podnose, a intravenski primijenjene dovode do porasta ukupnog kalcija, magnezija i neorganskog fosfora u krvi u trajanju od nekoliko sati.
Databáze: OpenAIRE
Externí odkaz: