Perinatal Aspects of SARS-CoV-2 Infection During Pregnancy: A Potential Cause for Concern

Autor: Potkonjak, Ana Meyra, Gall, Vesna, Milošević, Danko, Košec, Vesna, Filipović-Grčić, Boris
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Acta clinica Croatica
Volume 61.
Issue 4
ISSN: 1333-9451
0353-9466
Popis: Ever since the beginning of COVID-19 pandemic, uncertainty regarding clinical presentation and differences among various subpopulations exist. With more than 209,870,000 confirmed cases and more than 4,400,000 deaths worldwide, we are facing the new era of health crisis which will undoubtedly impair global health, economic and social circumstances. In the past year, numerous genetic mutations which code SARS-CoV-2 proteins led to the occurrence of new viral strains, with higher transmission rates. Apart from the implementation of vaccination, the effect of SARS-CoV-2 on pregnancy outcome and maternal fetal transmission remains an important concern. Although neonates diagnosed with COVID-19 were mostly asymptomatic or presented with mild disease, the effect on early pregnancy is yet to be evident. While positive finding of SARS-CoV-2 RNA in some samples such as amniotic fluid, placental tissue, cord blood and breast milk exists, additional research should confirm its association with transplacental transmission.
Od početka pandemije COVID-19 do danas tijek bolesti među različitim subpopulacijama ljudi nije do kraja poznat. Diljem svijeta potvrđeno je više od 209.870.000 oboljelih, ali i više od 4.400.000 smrtnih slučajeva. Nalazimo se u vremenu globalne krize, suočeni s njezinim posljedicama na zdravlje ljudi, ekonomiju i društvo. Protekle godine su brojne genske mutacije koje dovode do strukturnih promjena proteina SARS-CoV-2 dovele do pojave novih sojeva virusa s većom transmisijom. Bez obzira na uvođenje cijepljenja učinak SARS-CoV-2 na ishod trudnoće i prijenos virusa s majke na dijete i dalje su važan predmet interesa. Zasad je poznato da je novorođenčad s COVID-19 najčešće asimptomatska ili s blagom kliničkom slikom, a utjecaj infekcije na ranu trudnoću bit će tek vidljiv. Iako je RNK SARS-CoV-2 potvrđena u uzorcima plodove vode, posteljičnog tkiva, krvi pupkovine i u majčinu mlijeku potrebna su dodatna istraživanja koja će potvrditi njezinu povezanost s transplacentnim prijenosom.
Databáze: OpenAIRE
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