Supplementation with antioxidants in the treatment of Graves' disease: the effect on the extracellular antioxidative parameters

Autor: VESNA BACIC VRCA, FRANJO SKREB, IVANA CEPELAK, LJILJANA MAYER
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Acta Pharmaceutica
Volume 54
Issue 2
ISSN: 1846-9558
1330-0075
Popis: In this study, the effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) on concentrations of antioxidative parameters in serum was monitored. Measurements were performed prior to the commencement of therapy and after 30 and 60 days in patients with Graves' disease treated with methimazole. Patients who received extra supplementation with antioxidants (group A, n = 29) attained euthyroidism faster than the patients treated only with methimazole (group B, n = 28). Statistically significant differences were achieved after supplementation with antioxidants for all investigated parameters (uric acid, transferrin, ferritin), except TAS and glucose. Nevertheless, due to the fact that all measured parameters remained within the range of referent values, they may not be proposed as reliable indicators of the level of oxidative stress in Graves' disease.
U ovom istraživanju promatran jw učinak suplementacije fiksnom kombinacijom antioksidansa (vitamini C i E, β-karoten i selen) na koncentracije pokazatelja antioksidacijske obrane u serume. Mjerenja su obavljena u bolesnika s Graves-ovom bolešću liječenih metilmazolom (tiamazolom) prije početka terapije, te nakon 30 i 60 dana. Bolesnici, koji su uz metimazol imali i dodatnu terapiju s antioksidansima (skupina A, n=29), postizali su eutireozu brže od bolesnika koji su bili samo na terapiji metimazolom (skupina B, n=28). Koncencentracije svim mjernih parametara (urata, feritina i transferina), (osim koncentracije TAS-a i glukoze), značajno su se razlikovale među skupinama. Unatoč tomu, rezultati ove studije ukazuju na to kako se određivani parametri ne mogu smatrati dovoljno pouzdanim pokazateljima razine oksidacijskog stresa u Graves-ovoj bolesti, radi činjenice da su njihove koncentracije tijekom ispitivanja ostale unutar granica referentnih vrijednosti.
Databáze: OpenAIRE
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