Therapeutic Plasma Exchange in the Neurologic Intensive Care Setting: Recommendation for Clinical Practice

Autor: Petar Kes, Vanja Bašić-Kes, Nikolina Bašić-Jukić, Vida Demarin
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Acta clinica Croatica
Volume 51
Issue 1
ISSN: 1333-9451
0353-9466
Popis: Therapeutic plasma exchange (TPE ) is a well-established therapeutic procedure commonly used in many neurologic immune-mediated disorders. It is thought that the beneficial effects of TPE occur through elimination of pathognomonic autoantibodies, immune complexes, inflammatory mediators, complement components and cytokines, which play a crucial role in many kinds of neurologic autoimmune disease. In various neurologic disorders, randomized controlled studies have demonstrated the efficacy of TPE (e.g., in acute inflammatory demyelinating polyneuropathy (Guillain-Barré syndrome), chronic inflammatory demyelinating polyradiculoneuropathy, myasthenia gravis and paraproteinemic polyneuropathies). For these disorders, TPE is accepted as first-line therapy, either as a primary standalone treatment or in conjunction with other modes of treatment. Although widely used, the potential benefit of TPE in the treatment of acute disseminated encephalomyelitis, chronic focal encephalitis (Rasmussen’s encephalitis), Lambert-Eaton myasthenic syndrome, multiple sclerosis and neuromyelitis optica (Devic’s disease) is less clear. For these disorders, TPE is accepted as second-line therapy, either as a standalone treatment or in conjunction with other modes of treatment.
Terapijska izmjena plazme (TIP ) je dobro poznata terapijska metoda koju se rabi u liječenju brojnih imuno posredovanih neuroloških bolesti. Povoljni učinci TIP ostvaruju se uklanjanjem plazmatskih uzročnika bolesti odnosno autoantitjela, imunih kompleksa, posrednika upale, sastavnica komplementa i citokina koji imaju ključnu ulogu u nastanku neuroloških autoimunih bolesti. Randomizirana, kontrolirana istraživanja dokazala su učinkovitost TIP u liječenju slijedećih neuroloških bolesti: akutna upalna demijelinizirajuća polineuropatija (AUDP; Guillain-Barréov sindrom), kronična upalna demijelinizirajuća poliradikulopatija (KUDP), mijastenija gravis (MG ) i paraproteinemijske polineuropatije (PP ). U tim je bolestima TIP prihvaćena kao prvi izbor liječenja, kao jedina metoda ili u kombinaciji s drugim terapijskim metodama. Učinkovitost liječenja pomoću TIP manje je uvjerljiva u neurološkim bolestima kao što su akutni diseminirani encefalomijelitis (ADEM ), kronični fokalni encefalitis (Rasmussenov encefalitis), Lambert-Eatonov mijastenični sindrom (LEMS ), multipla skleroza (MS ) i optički neuromijelitis (ON ; Deviceva bolest). U tim bolestima TIP je prihvaćena kao drugi izbor liječenja, i to kao jedina metoda ili u kombinaciji s drugim vrstama liječenja.
Databáze: OpenAIRE