Antibiotic Resistance of Gram-Positive Bacteria at the Sestre Milosrdnice University Hospital
| Autor: | Ines Benčić, Ivan Benčić |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Acta clinica Croatica Volume 40 Issue 1 |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | The study was performed to provide current resistance data on gram-positive pathogens at the Sestre milosrdnice University Hospital in Zagreb. The organisms selected for monitoring of antimicrobial resistance to different antibiotics included Streptococcus pneumoniae, Streptococcus pyogenes, methicillin sensitive and resistant Staphylococcus aureus, and Enterococcus sp., isolated from different clinical specimens of hospitalized adults and children from various Hospital wards. The antibiotic sensitivity testing was performed by disk diffusion and E-test method. Resistance of Streptococcus pneumoniae to penicillin was found to be of great importance. It was quite common but moderate, so penicillin remained an appropriate choice in empirical therapy for presumed pneumococcal respiratory infections. Resistance of Streptococcus pyogenes to azithromycin was also quite significant, posing a question whether macrolides were an appropriate choice in empirical therapy for presumed Streptococcus pyogenes tonsillopharyngitis. As many as 38% of Enterococcus sp. could not be treated by a combination of penicillin or glycopeptide and gentamicin because of the high - level resistance to gentamicin. Resistance to antibiotics in methicillin sensitive Staphylococcus aureus was not observed. Antibiotic resistance data on gram-positive pathogens influence the choice of local empirical therapy and allow for a more rational use of antibiotics at a hospital. Cilj istraživanja bio je pratiti otpornost gram-pozitivnih uzročnika na antibiotike u Kliničkoj bolnici “Sestre milosrdnice” u Zagrebu. Otpornost na antibiotike pratila se za sljedeće gram-pozitivne uzročnike: Streptococcus pneumoniae, Streptococcus pyogenes, na meticilin osjetljiv i rezistentan Staphylococcus aureus te Enterococcus sp., koji su izolirani iz kliničkih materijala hospitaliziranih odraslih osoba i djece. Testiranje osjetljivosti na antibiotike provedeno je pomoću difuzijske metode i E-testom. Vrlo je značajan bio problem otpornosti Streptococcus pneumoniae na penicilin. Ova je otpornost bila vrlo česta, ali je umjerena, što znači da penicilin i dalje ostaje prikladnim antibiotikom u empirijskoj terapiji pretpostavljenih pneumokoknih respiracijskih infekcija. Otpornost Streptococcus pyogenes na azitromicin bila je također značajna, pa se postavlja pitanje jesu li makrolidi prikladni antibiotici u empirijskoj terapiji gnojnih angina. Čak 38% Enterococcus sp. ne može se liječiti kombinacijom penicilina ili glikopeptida i gentamicina zbog visoke otpornosti enterokoka na gentamicin. Otpornost na antibiotike kod Staphylococcus aureus osjetljivih na meticilin nije bila česta. Otpornost na vankomicin kod Staphylococcus aureus otpornih na meticilin nije zabilježena. Podaci o otpornosti gram-pozitivnih uzročnika na antibiotike utječu na izbor lokalne empirijske terapije i omogućavaju racionalniju potrošnju antibiotika u bolnici. |
| Databáze: | OpenAIRE |
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